This topic will discuss the pathologic pharmacology, mechanisms, and clinical presentation of toxicity, predisposing factors, and prevention and management of LAST. This article talks about how lidocaine overdose happens, the signs and symptoms of lidocaine toxicity, and what to do if you think you've received or taken too much lidocaine. Local anesthetic systemic toxicity (LAST) is a rare complication that can develop within minutes of receiving local anesthetics. It’s a medical emergency that causes nervous system and heart issues. Lidocaine is a local anesthetic and generally safe. However, it is possible to develop direct nerve and systemic toxicity with too much lidocaine. Understanding potential adverse reactions, such as lidocaine toxicity, is important for patient well-being. This article explains what lidocaine toxicity involves, its causes, how to recognize its signs, and its management and prevention. Toxicity from local anesthetics, including lidocaine, is clinically termed Local Anesthetic Systemic Toxicity (LAST). It is a rare but potentially life-threatening condition, affecting the central nervous system (CNS) and the cardiovascular system. ADRs associated with the use of intravenous lidocaine are similar to the toxic effects of systemic exposure above. These are dose-related and more frequent at high infusion rates (≥3 mg/min). Learn about the side effects of lidocaine, from common to rare, for consumers and healthcare professionals. Local Anesthetic Systemic Toxicity (LAST) refers to the effects, signs, and symptoms that systemic absorption of local anesthetic (LA) has on the body. For more acute poisoning with a shorter anticipated duration (e.g., local anesthetic systemic toxicity), higher doses may be reasonable for a shorter period (e.g., 500-1,000 ml infused over 30-60 minutes).